Odontogenic keratocysts make up around 19% of jaw cysts. The adenomatoid odontogenic tumor is an odontogenic tumor arising from the enamel organ or dental lamina. Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary antrum. Adenomatoid odontogenic tumor aot is a wellrecognised slow growing benign tumor derived from complex system of dental lamina or its remnants. This lesion is most commonly associated with an impacted maxillary canine. Generally, recurrences seldom, if ever, occur after surgical curettage, while here we report an extremely rare case of aot with recurrence.
Adenomatoid odontogenic tumor a report of two cases with. In other words, odontogenic tumors arise from odontogenic tissues. The adenomatoid odontogenic tumor aot is a relatively uncommon lesion which mainly affects females in their second decade of life, exhibiting predilection for the. Adenomatoid odontogenic tumour aot was generally considered as an uncommon disease that occurred in the maxillofacial region, accounting for 2. In the pathogenesis of odontogenic tumors which arise from the rests of the dental apparatus in the jaw, several molecular pathways have been shown to play critical roles such as genetic alterations in the hedgehog, brafrasmapk, epidermal growth factor receptor. Case report cystic adenomatoid odontogenic tumor sonalgrover, 1 ahmedmujibbangalorerahim, 2 nithinkavasseryparakkat, 3 shekharkapoor, 4 kumudmittal, 5 bhushansharma, 1 andanilbangaloreshivappa 6 department of oral pathology and microbiology, christian dental college, cmc, ludhiana, punjab, india. Based on its tooth association, aot can be classified into three categories of follicular, extrafollicular, and peripheral types. An adenomatoid odontogenic tumor aot is a rare, benign epithelial odontogenic tumor which accounts for 27% of all odontogenic tumors. Introduction adenomatoid odontogenic tumor aot is an uncommon, benign epithelial lesion of odontogenic origin, representing approximately 3% of all odontogenic tumors 1. Adenomatoid odontogenic tumorreport of a posterior. D, frcpath assistant prof of general pathology senior lecturer of oral pathology and oral histology slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Adenomatoid odontogenic tumor aot is a benign lesion from the dental lamina or its remains. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. Adenomatoid odontogenic tumor aot is a relatively uncommon odontogenic tumor characterized by the formation of ductlike structures by the epithelial component of the. The tumor occurs more frequently in females with a ratio of 2. Adenomatoid odontogenic tumor aot is an uncommon benign odontogenic lesion that affects young patients associated with an impacted tooth, usually canine. The tumor which today is called adenomatoid odontogenic tumor aot was probably first described by dreibladt 1907, quoted in thoma 1970, who called the tumor pseudoadenoma adamantinum, and then by harbitz 1915, who called it adamantine cystadenoma gorlin and. Adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade.
This epithelial tumor has an inductive effect on the odontogenic ectomesenchyme with dentinoid frequently being produced. The current world health organisation who classification of odontogenic tumors defines aot as being composed of the odontogenic epithelium in a variety of histoarchitectural patterns, embedded in mature connective tissue stroma, and characterized by slow, but progressive growth. It is well known for its unique histopathologic features, predilection for young individuals, and innocuous behavior. Adenomatoid odontogenic tumors pdf adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. It has two clinicopathologic variants, namely intraosseous follicular and. The origin of odontogenic tumors odontogenic tissues ectodermal mesenchymalepithelium c. In the past, this tumor has been referred to as adenoameloblastoma or ameloblastic adenomatoid tumor. It appears mostly in young patients and females, the maxillary region being the most affected. Adenomatoid odontogenic tumor aot is an uncommon tumor of odontogenic origin. Ranking four among the odontogenic tumors the aot is not a particularly rare tumor. Adenomatoid odontogenic tumor aot is a slow growing, benign. Adenomatoid odontogenic tumor case report case report vol.
The aim of this update was to present the recent notable progress within remaining questions relating to the adenomatoid odontogenic tumour aot. Overall, odontogenic tumors are rare and form only a small proportion of the lesions found in the jaw. We report two cases of an exceptional combination of these tumors with either an ameloblastic fibroodontoma or an odontoma. Aot accounts for about 1% until 9% of all odontogenic tumors. Dentigerous cyst associated with adenomatoid odontogenic. It is common for the tumor to cause shifting of neighboring teeth because tumor expansion is more common than teeth root resorption. Characteristic features of the adenomatoid odontogenic. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst and accounts for about 1% until 9% of all odontogenic tumors. It is a benign hamartomatous, noninvasive lesion with slow but progressive growth. Adenomatoid odontogenic tumor is also called twothirds tumor, because 23 rd of adenomatoid tumors occur in the maxilla, 23 rd occur in young females, twothirds of the cases are associated with unerupted teeth, and twothirds of the affected teeth are canines.
Adenomatoid odontogenic tumor aot is a rare noninvasive odontogenic tumor that occurs mostly in the second decade of life. Adenomatoid odontogenic tumour is a benign hamartomatous, noninvasive lesion with slow but progressive growth. Adenomatoid odontogenic tumor associated with an impacted. Molecular profiling of odontogenic tumors pilot study in. It is predominantly found in young and female patients, located more often in the. Although they do not normally contain odontogenic tissue, they are probably odontogenic because of their site of origin. This article describes a case of extrafollicular adenomatoid odontogenic tumor in a yearold male, located in the maxilla treated by enucleation.
Calcifying epithelial odontogenic tumors ceots and calcifying odontogenic cysts cocs are rare, benign odontogenic tumors. Adenomatoid odontogenic tumor aot is a benign neoplasm of odontogenic epithelium. Adenomatoid odontogenic tumor aot is a distinct odontogenic tumor that is exclusively odontogenic epithelium in origin which accounts for about 37% of all odontogenic tumors. Adenomatoid odontogenic tumor aot is an uncommon tumor of odontogenic origin, composed of odontogenic epithelium in a variety of histoarchitectural patterns, and characterized by slow but progressive growth. Conservative surgical excision is the treatment of choice. Adenomatoid odontogenic tumorreport of a posterior mandibular case with the presence of ghost cells. It is a benign, painless, noninvasive, and slowgrowing lesion, with a relative frequency of 2. The 3 variantsfollicular, extrafollicular and peripheralpresent with identical histological findings. Adenomatoid odontogenic tumour aot is an uncommon, hamartomatous, benign epitheial lesion of odontogenic origin. An extrafollicular adenomatoid odontogenic tumor mimicking. When grown, one can palpate a hard and large lesion. The radiographical differentiation of adenomatoid odontogenic tumor aot from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult.
We attempted to differentiate aot from other lesions similar to aot in radiographic findings using mri. Abstract adenomatoid odontogenic tumor aota benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade. This paper reported a case of aot, in a 16yearold female, associated with an impacted maxillary left lateral incisor. The recently revised who classification of odontogenic tumors defines an aot as a tumor composed of odontogenic epithelium in a variety of histoarchitectural patterns, embedded in a mature connective tissue stroma and characterized by. Adenomatoid odontogenic tumor aot formerly called an adenoameloblastoma, a somewhat deceptive term that should be discarded, the aot represents about 37 % of all odontogenic tumors. View enhanced pdf access article on wiley online library html view download pdf. It is predominantly found in young and female patients, located more often in the maxilla in most cases associated with an unerupted permanent tooth. A, e multiple epithelial follicles with calcifications arrows.
It is a relatively uncommon neoplasm that accounts for about 3% of all odontogenic tumors being more. The adenomatoid odontogenic tumor is a hamartomatous benign neoplasia of odontogenic origin. Assessment of mri and dynamic contrastenhanced mri in the. Several tumors exist, which only appear to occur in the jaws. The patient is in postoperative followup, without any clinical and radiographic signs of lesion recurrence. Ameloblastomas and adenomatoid odontogenic tumors aots are common epithelial tumors of odontogenic origin. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Adenomatoid odontogenic tumor aot is a rare tumor of epithelial origin comprising 3% of all the odontogenic tumors. The adenomatoid odontogenic tumor aot is usually an asymptomatic slow growth lesion. Adenomatoid odontogenic tumor aot is a benign lesion from the dental lamina or its. Hiromasa hasegawa and hideaki kagami, a case of adenomatoid odontogenic tumor with unusual presentation. Author links open overlay panel mingjane lang a yiping wang b c hungpin lin b c hsinming chen b c d.
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